InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RGS14

Summary

InnateDB Gene

IDBG-645245.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS14

Gene Name

regulator of G-protein signaling 14

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008497

Encoded Proteins

IDBP-697939

regulator of G-protein signaling 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169220:
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:40214182-40227956

Strand

Forward strand

Band

Transcripts

ENSBTAT00000011200

ENSBTAP00000011200

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005092	GDP-dissociation inhibitor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0030695	GTPase regulator activity
GO:0032794	GTPase activating protein binding

Biological Process

GO:0006913	nucleocytoplasmic transport
GO:0007051	spindle organization
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0007612	learning
GO:0007616	long-term memory
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0010070	zygote asymmetric cell division
GO:0031914	negative regulation of synaptic plasticity
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043407	negative regulation of MAP kinase activity
GO:0043620	regulation of DNA-dependent transcription in response to stress
GO:0051301	cell division
GO:0060291	long-term synaptic potentiation