InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PROP1

Summary

InnateDB Gene

IDBG-645354.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PROP1

Gene Name

Homeobox protein prophet of Pit-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007359

Encoded Proteins

IDBP-698056

homeobox protein prophet of Pit-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175325:
This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:41205895-41209917

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009680

ENSBTAP00000009680

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0006355	regulation of transcription, DNA-templated
GO:0009887	organ morphogenesis
GO:0009953	dorsal/ventral pattern formation
GO:0016477	cell migration
GO:0021979	hypothalamus cell differentiation
GO:0021984	adenohypophysis development
GO:0043066	negative regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048732	gland development
GO:0048850	hypophysis morphogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0060126	somatotropin secreting cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000175325

View Gene Order

ENSMUSG00000044542

View Gene Order

Cross-References

SwissProt

Q8MJI9

TrEMBL

A7TZP9

UniProt Splice Variant

Entrez Gene

282563

UniGene

Bt.11213

RefSeq

NM_174678

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF453510 AF453511 AF453512 EF518217 EF518218 EF518219 EF518220 EF518221 EF518222 EF518223 EF518224 EF518225 EF518226 EF518227 EF518228 EF518229 EF518230 EF518231 EF518232 EF518233 EF518234

GenPept

AAM22639 AAM22640 AAM22641 ABU41808 ABU41809 ABU41810 ABU41811 ABU41812 ABU41813 ABU41814 ABU41815 ABU41816 ABU41817 ABU41818 ABU41819 ABU41820 ABU41821 ABU41822 ABU41823 ABU41824 ABU41825

RNA Seq Atlas

282563