Version 5.4
Homo sapiens Gene: PROP1
Summary
InnateDB Gene IDBG-60638.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROP1
Gene Name PROP paired-like homeobox 1
Synonyms CPHD2; PROP-1
Species Homo sapiens
Ensembl Gene ENSG00000175325
Encoded Proteins
IDBP-60640
PROP paired-like homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:177992235-177996242
Strand Reverse strand
Band q35.3
Transcripts
ENST00000308304 ENSP00000311290
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0007417 central nervous system development
GO:0009887 organ morphogenesis
GO:0009953 dorsal/ventral pattern formation
GO:0016477 cell migration
GO:0021979 hypothalamus cell differentiation
GO:0021984 adenohypophysis development
GO:0043066 negative regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048732 gland development
GO:0048850 hypophysis morphogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0060126 somatotropin secreting cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044542
View Gene Order
ENSBTAG00000007359
Not yet available
Cross-References
SwissProt O75360
TrEMBL
UniProt Splice Variant
Entrez Gene 5626
UniGene Hs.158301
RefSeq NM_006261
HUGO HGNC:9455
OMIM 601538
CCDS CCDS4430
HPRD 03325
IMGT
EMBL AC136940 AF041139 AF041140 AF041141 AF076214 AF076215 BC069076
GenPept AAC27900 AAC77453 AAC77454 AAH69076
RNA Seq Atlas 5626

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca