Version 5.4
Bos taurus Gene: SLC24A1
Summary
InnateDB Gene IDBG-645381.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC24A1
Gene Name Sodium/potassium/calcium exchanger 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000025826
Encoded Proteins
IDBP-698087
Sodium/potassium/calcium exchanger 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074621:
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:12469673-12498031
Strand Forward strand
Band
Transcripts
ENSBTAT00000036529 ENSBTAP00000036386
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008273 calcium, potassium:sodium antiporter activity
GO:0015293 symporter activity
GO:0015297 antiporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006816 calcium ion transport
GO:0007601 visual perception
GO:0035725 sodium ion transmembrane transport
GO:0050896 response to stimulus
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000074621
View Gene Order
ENSMUSG00000034452
View Gene Order
Pathways
NETPATH
REACTOME
REACT_222460
SLC-mediated transmembrane transport pathway
REACT_217379
Sodium/Calcium exchangers pathway
REACT_205562
The phototransduction cascade pathway
REACT_223698
Visual phototransduction pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_211562
Activation of the phototransduction cascade pathway
REACT_203377
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_214353
Signal Transduction pathway
REACT_216038
Diseases associated with visual transduction pathway
REACT_207087
Disease pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19320
Sodium/Calcium exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_163932
Activation of the phototransduction cascade pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_163722
The phototransduction cascade pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_116125
Disease pathway
KEGG
hsa04744
Phototransduction pathway
mmu04744
Phototransduction pathway
INOH
PID NCI
rhodopsin_pathway
Visual signal transduction: Rods
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.19
RefSeq NM_174655
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca