Version 5.4
Bos taurus Protein: SLC24A1
Summary
InnateDB Protein IDBP-698087.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC24A1
Protein Name Sodium/potassium/calcium exchanger 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000036386
InnateDB Gene IDBG-645381 (SLC24A1)
Protein Structure
UniProt Annotation
Function Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Retina.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008273 calcium, potassium:sodium antiporter activity
GO:0015293 symporter activity
GO:0015297 antiporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006816 calcium ion transport
GO:0007601 visual perception
GO:0035725 sodium ion transmembrane transport
GO:0050896 response to stimulus
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004481 Sodium/potassium/calcium exchanger
IPR004817 K+-dependent Na+/Ca+ exchanger
IPR004837 Sodium/calcium exchanger membrane region
PFAM PF01699
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q28139
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282474
UniGene Bt.19
RefSeq NP_777080
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF025664 X66481
GenPept AAB88884 CAA47108

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca