InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.31482

Summary

InnateDB Gene

IDBG-645421.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.31482

Gene Name

voltage-dependent L-type calcium channel subunit alpha-1D

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010026

Encoded Proteins

IDBP-698136

Voltage-dependent calcium channel subunit alpha 1D

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157388:
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:47721360-48066942

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000013226

ENSBTAP00000013226

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity
GO:0030506	ankyrin binding
GO:0051393	alpha-actinin binding
GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007605	sensory perception of sound
GO:0034765	regulation of ion transmembrane transport
GO:0051928	positive regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0086010	membrane depolarization during action potential
GO:0086046	membrane depolarization involved in regulation of SA node cell action potential
GO:0086052	membrane repolarization during SA node cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:1901016	regulation of potassium ion transmembrane transporter activity
GO:1901379	regulation of potassium ion transmembrane transport