InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cacna1d

Summary

InnateDB Gene

IDBG-142439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cacna1d

Gene Name

calcium channel, voltage-dependent, L type, alpha 1D subunit

Synonyms

8430418G19Rik; C79217; Cacnl1a2; Cchl1a; Cchl1a2; D-LTCC

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015968

Encoded Proteins

IDBP-256403

calcium channel, voltage-dependent, L type, alpha 1D subunit

IDBP-256405

calcium channel, voltage-dependent, L type, alpha 1D subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157388:
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:30039949-30491156

Strand

Reverse strand

Band

Transcripts

ENSMUST00000112250	ENSMUSP00000107869
ENSMUST00000112249	ENSMUSP00000107868

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity
GO:0030506	ankyrin binding
GO:0046872	metal ion binding
GO:0051393	alpha-actinin binding
GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007605	sensory perception of sound
GO:0051928	positive regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0086046	membrane depolarization involved in regulation of SA node cell action potential
GO:0086052	membrane repolarization during SA node cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:1901016	regulation of potassium ion transmembrane transporter activity
GO:1901379	regulation of potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0030018	Z disc