Version 5.4
Bos taurus Gene: SMAD3
Summary
InnateDB Gene IDBG-645466.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMAD3
Gene Name mothers against decapentaplegic homolog 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012599
Encoded Proteins
IDBP-698167
SMAD family member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:13958174-13980371
Strand Forward strand
Band
Transcripts
ENSBTAT00000016728 ENSBTAP00000016728
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0000988 protein binding transcription factor activity
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0042803 protein homodimerization activity
GO:0043130 ubiquitin binding
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0070410 co-SMAD binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001657 ureteric bud development
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0001889 liver development
GO:0001933 negative regulation of protein phosphorylation
GO:0001947 heart looping
GO:0002076 osteoblast development
GO:0002520 immune system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006810 transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955 immune response
GO:0007050 cell cycle arrest
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0007369 gastrulation
GO:0007492 endoderm development
GO:0009880 embryonic pattern specification
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016202 regulation of striated muscle tissue development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0019049 evasion or tolerance of host defenses by virus
GO:0030308 negative regulation of cell growth
GO:0030878 thyroid gland development
GO:0032332 positive regulation of chondrocyte differentiation
GO:0032909 regulation of transforming growth factor beta2 production
GO:0032924 activin receptor signaling pathway
GO:0033689 negative regulation of osteoblast proliferation
GO:0035413 positive regulation of catenin import into nucleus
GO:0035556 intracellular signal transduction
GO:0038092 nodal signaling pathway
GO:0042110 T cell activation
GO:0042177 negative regulation of protein catabolic process
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0045216 cell-cell junction organization
GO:0045668 negative regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048340 paraxial mesoderm morphogenesis
GO:0048589 developmental growth
GO:0048617 embryonic foregut morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050678 regulation of epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0050776 regulation of immune response
GO:0050821 protein stabilization
GO:0051098 regulation of binding
GO:0060039 pericardium development
GO:0061045 negative regulation of wound healing
GO:0070306 lens fiber cell differentiation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:1901313 positive regulation of gene expression involved in extracellular matrix organization
Cellular Component
GO:0000790 nuclear chromatin
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0043235 receptor complex
GO:0071141 SMAD protein complex
GO:0071144 SMAD2-SMAD3 protein complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL F1MUZ3
UniProt Splice Variant
Entrez Gene 515125
UniGene Bt.91690
RefSeq NM_001205805
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02027904
GenPept
RNA Seq Atlas 515125

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca