InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SMAD3

Summary

InnateDB Protein

IDBP-698167.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMAD3

Protein Name

SMAD family member 3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016728

InnateDB Gene

IDBG-645466 (SMAD3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0000988	protein binding transcription factor activity
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005160	transforming growth factor beta receptor binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding
GO:0019902	phosphatase binding
GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031490	chromatin DNA binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity
GO:0043130	ubiquitin binding
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070410	co-SMAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001649	osteoblast differentiation
GO:0001657	ureteric bud development
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001707	mesoderm formation
GO:0001756	somitogenesis
GO:0001889	liver development
GO:0001933	negative regulation of protein phosphorylation
GO:0001947	heart looping
GO:0002076	osteoblast development
GO:0002520	immune system development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955	immune response
GO:0007050	cell cycle arrest
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007183	SMAD protein complex assembly
GO:0007369	gastrulation
GO:0007492	endoderm development
GO:0009880	embryonic pattern specification
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0016202	regulation of striated muscle tissue development
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0019049	evasion or tolerance of host defenses by virus
GO:0030308	negative regulation of cell growth
GO:0030878	thyroid gland development
GO:0032332	positive regulation of chondrocyte differentiation
GO:0032909	regulation of transforming growth factor beta2 production
GO:0032924	activin receptor signaling pathway
GO:0033689	negative regulation of osteoblast proliferation
GO:0035413	positive regulation of catenin import into nucleus
GO:0035556	intracellular signal transduction
GO:0038092	nodal signaling pathway
GO:0042110	T cell activation
GO:0042177	negative regulation of protein catabolic process
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0045216	cell-cell junction organization
GO:0045668	negative regulation of osteoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045930	negative regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048340	paraxial mesoderm morphogenesis
GO:0048589	developmental growth
GO:0048617	embryonic foregut morphogenesis
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0050678	regulation of epithelial cell proliferation
GO:0050728	negative regulation of inflammatory response
GO:0050776	regulation of immune response
GO:0050821	protein stabilization
GO:0051098	regulation of binding
GO:0060039	pericardium development
GO:0061045	negative regulation of wound healing
GO:0070306	lens fiber cell differentiation
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:1901313	positive regulation of gene expression involved in extracellular matrix organization

Cellular Component

GO:0000790	nuclear chromatin
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005637	nuclear inner membrane
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0043235	receptor complex
GO:0071141	SMAD protein complex
GO:0071144	SMAD2-SMAD3 protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001132 SMAD domain, Dwarfin-type
IPR003619 MAD homology 1, Dwarfin-type
IPR008984 SMAD/FHA domain
IPR013019 MAD homology, MH1
IPR019471 Interferon regulatory factor-3

PFAM

PF03166
PF03165
PF10401

PRINTS

PIRSF

SMART

SM00524
SM00523

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite