InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CLDN11

Summary

InnateDB Gene

IDBG-64549.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLDN11

Gene Name

claudin 11

Synonyms

OSP; OTM

Species

Homo sapiens

Ensembl Gene

ENSG00000013297

Encoded Proteins

IDBP-64551

claudin 11

IDBP-484758

claudin 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:170418865-170860380

Strand

Forward strand

Band

q26.2

Transcripts

ENST00000064724	ENSP00000064724
ENST00000486975	ENSP00000417434
ENST00000486429
ENST00000489485
ENST00000468358
ENST00000471373
ENST00000477531
ENST00000488989
ENST00000480067

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007283	spermatogenesis
GO:0008366	axon ensheathment
GO:0016338	calcium-independent cell-cell adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0045178	basal part of cell
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037625

View Gene Order

ENSBTAG00000019060

Not yet available

Pathways

NETPATH

REACTOME

REACT_19373

Tight junction interactions pathway

REACT_111155

Cell-Cell communication pathway

REACT_20676

Cell junction organization pathway

REACT_19331

Cell-cell junction organization pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04670

Leukocyte transendothelial migration pathway

hsa04530

Tight junction pathway

hsa05160

Hepatitis C pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.407600 Hs.599737

RefSeq

NM_005602

HUGO

OMIM

CCDS

CCDS3213

HPRD

03207

IMGT

EMBL

GenPept

RNA Seq Atlas