InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: C1QC

Summary

InnateDB Gene

IDBG-645502.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C1QC

Gene Name

complement C1q subcomponent subunit C precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011193

Encoded Proteins

IDBP-698209

C1QC proteinUncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 15207504

[Homo sapiens] C1QC is the C-chain of the C1Q recognition subunit of Complement component 1 (C1), and acts a multimolecular protease that triggers the classical pathway of complement and has a major role in the host defence against pathogens.

PMID 20381531

[Homo sapiens] C1Q is involved in the modulation of various immune cells such as dendritic cells, platelets, microglia cells and lymphocytes. C1Q has roles in clearance of apoptotic cells as well as a range of cell processes such as differentiation, chemotaxis, aggregation and adhesion, and pathogenesis of neurodegenerative diseases.

PMID 21450789

[Homo sapiens] C1QA :: C1QB :: C1QC (C1Q) is a versatile innate immune molecule that recognizes an array of self, non-self and altered-self ligands. The broad-spectrum of ligand specificity is facilitated by the modular organization of the heterotrimeric globular region and its ability to change its confirmation.

PMID 21450789

[Mus musculus] C1qa :: C1qb :: C1qc (C1q) is a versatile innate immune molecule that recognizes an array of self, non-self and altered-self ligands. The broad-spectrum of ligand specificity is facilitated by the modular organization of the heterotrimeric globular region and its ability to change its confirmation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159189:
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:130783987-130788357

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000014865

ENSBTAP00000014865

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0030853	negative regulation of granulocyte differentiation
GO:0045650	negative regulation of macrophage differentiation

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle