Version 5.4
| Homo sapiens Gene: C1QC | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-93737.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | C1QC | ||||||||||||||||||
| Gene Name | complement component 1, q subcomponent, C chain | ||||||||||||||||||
| Synonyms | C1Q-C; C1QG | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000159189 | ||||||||||||||||||
| Encoded Proteins |
complement component 1, q subcomponent, C chain
complement component 1, q subcomponent, C chain
complement component 1, q subcomponent, C chain
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
C1QC is the C-chain of the C1Q recognition subunit of Complement component 1 (C1), and acts a multimolecular protease that triggers the classical pathway of complement and has a major role in the host defence against pathogens.
C1Q is involved in the modulation of various immune cells such as dendritic cells, platelets, microglia cells and lymphocytes. C1Q has roles in clearance of apoptotic cells as well as a range of cell processes such as differentiation, chemotaxis, aggregation and adhesion, and pathogenesis of neurodegenerative diseases.
C1QA :: C1QB :: C1QC (C1Q) is a versatile innate immune molecule that recognizes an array of self, non-self and altered-self ligands. The broad-spectrum of ligand specificity is facilitated by the modular organization of the heterotrimeric globular region and its ability to change its confirmation.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||
| Summary |
[Mus musculus] C1qa :: C1qb :: C1qc (C1q) is a versatile innate immune molecule that recognizes an array of self, non-self and altered-self ligands. The broad-spectrum of ligand specificity is facilitated by the modular organization of the heterotrimeric globular region and its ability to change its confirmation.
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:22643630-22648110 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p36.12 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Classical antibody-mediated complement activation pathway
Initial triggering of complement pathway
Innate Immune System pathway
Creation of C4 and C2 activators pathway
Immune System pathway
Complement cascade pathway
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| KEGG |
Complement and coagulation cascades pathway
Systemic lupus erythematosus pathway
Prion diseases pathway
Staphylococcus aureus infection pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P02747 | ||||||||||||||||||
| TrEMBL | A0A024RAA7 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 714 | ||||||||||||||||||
| UniGene | Hs.602329 | ||||||||||||||||||
| RefSeq | NM_001114101 NM_172369 | ||||||||||||||||||
| HUGO | HGNC:1245 | ||||||||||||||||||
| OMIM | 120575 | ||||||||||||||||||
| CCDS | CCDS227 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF087892 AK057792 AL158086 BC009016 CH471134 | ||||||||||||||||||
| GenPept | AAH09016 AAP97191 BAB71575 CAI22894 EAW95016 EAW95017 EAW95018 | ||||||||||||||||||
| RNA Seq Atlas | 714 | ||||||||||||||||||