InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ALPL

Summary

InnateDB Gene

IDBG-645614.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALPL

Gene Name

Alkaline phosphatase, tissue-nonspecific isozyme

Synonyms

TNS-AP

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008951

Encoded Proteins

IDBP-698335

Alkaline phosphatase, tissue-nonspecific isozyme

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162551:
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:131791680-131857642

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000011783

ENSBTAP00000011783

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004035	alkaline phosphatase activity
GO:0005515	protein binding
GO:0016462	pyrophosphatase activity
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0001958	endochondral ossification
GO:0003006	developmental process involved in reproduction
GO:0008152	metabolic process
GO:0016311	dephosphorylation
GO:0031214	biomineral tissue development
GO:0033280	response to vitamin D
GO:0046677	response to antibiotic
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0031225	anchored component of membrane
GO:0065010	extracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000162551

View Gene Order

ENSMUSG00000028766

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

hsa00790

Folate biosynthesis pathway

mmu00790

Folate biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

P09487

TrEMBL

UniProt Splice Variant

Entrez Gene

280994

UniGene

Bt.13670

RefSeq

NM_176858 XM_005203065 XM_005203066 XM_005203067 XM_005203068 XM_005203069

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC118208 M18443

GenPept

AAA30380 AAI18209

RNA Seq Atlas

280994