Version 5.4
Bos taurus Protein: ALPL
Summary
InnateDB Protein IDBP-698335.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALPL
Protein Name Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms TNS-AP;
Species Bos taurus
Ensembl Protein ENSBTAP00000011783
InnateDB Gene IDBG-645614 (ALPL)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cell membrane; Lipid-anchor, GPI-anchor.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004035 alkaline phosphatase activity
GO:0005515 protein binding
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0001958 endochondral ossification
GO:0003006 developmental process involved in reproduction
GO:0008152 metabolic process
GO:0016311 dephosphorylation
GO:0031214 biomineral tissue development
GO:0033280 response to vitamin D
GO:0046677 response to antibiotic
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0031225 anchored component of membrane
GO:0065010 extracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001952 Alkaline phosphatase
IPR017850 Alkaline-phosphatase-like, core domain
PFAM PF00245
PRINTS PR00113
PIRSF
SMART SM00098
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P09487
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280994
UniGene Bt.13670
RefSeq NP_789828
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118208 M18443
GenPept AAA30380 AAI18209

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca