InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CDA

Summary

InnateDB Gene

IDBG-645661.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDA

Gene Name

cytidine deaminase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006136

Encoded Proteins

IDBP-698388

cytidine deaminase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158825:
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:132636462-132657392

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008074

ENSBTAP00000008074

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001882	nucleoside binding
GO:0003824	catalytic activity
GO:0004126	cytidine deaminase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0009972	cytidine deamination
GO:0030308	negative regulation of cell growth
GO:0045980	negative regulation of nucleotide metabolic process
GO:0051289	protein homotetramerization