Version 5.4
Bos taurus Gene: NBL1
Summary
InnateDB Gene IDBG-645714.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NBL1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005140
Encoded Proteins
IDBP-698453
neuroblastoma, suppression of tumorigenicity 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158747:
This locus represents naturally occurring read-through transcription between the neighboring chromosome 1 open reading frame 151 (GeneID 440574) and neuroblastoma suppressor of tumorigenicity 1 (GeneID 4681) genes on chromosome 1. The read-through transcripts produce at least two proteins, each of which share identity with proteins translated from the downstream neuroblastoma suppressor of tumorigenicity 1 locus. [provided by RefSeq, Feb 2011] This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream chromosome 1 open reading frame 151 locus (GeneID 440574) have been observed.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:133632742-133634622
Strand Reverse strand
Band
Transcripts
ENSBTAT00000006779 ENSBTAP00000006779
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016015 morphogen activity
GO:0036122 BMP binding
Biological Process
GO:0007399 nervous system development
GO:0030514 negative regulation of BMP signaling pathway
GO:0035582 sequestering of BMP in extracellular matrix
GO:0045666 positive regulation of neuron differentiation
GO:0048263 determination of dorsal identity
GO:0048812 neuron projection morphogenesis
GO:0090027 negative regulation of monocyte chemotaxis
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000158747
View Gene Order
ENSMUSG00000041120
View Gene Order
Cross-References
SwissProt
TrEMBL F1MNJ9
UniProt Splice Variant
Entrez Gene 535280
UniGene
RefSeq XM_002685791 XM_615319
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02006520
GenPept
RNA Seq Atlas 535280

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca