Version 5.4
Bos taurus Gene: SEC24A
Summary
InnateDB Gene IDBG-645809.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC24A
Gene Name Protein transport protein Sec24A
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018322
Encoded Proteins
IDBP-698564
Protein transport protein Sec24A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113615:
The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:47754927-47832191
Strand Forward strand
Band
Transcripts
ENSBTAT00000043111 ENSBTAP00000040703
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0045714 regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0050714 positive regulation of protein secretion
GO:2000189 positive regulation of cholesterol homeostasis
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0030127 COPII vesicle coat
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000113615
View Gene Order
ENSMUSG00000036391
View Gene Order
Pathways
NETPATH
REACTOME
REACT_218212
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
REACT_214728
Transport to the Golgi and subsequent modification pathway
REACT_212672
Class I MHC mediated antigen processing & presentation pathway
REACT_213138
Immune System pathway
REACT_223866
Asparagine N-linked glycosylation pathway
REACT_211133
MHC class II antigen presentation pathway
REACT_213782
Metabolism of proteins pathway
REACT_214405
Post-translational protein modification pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_225088
ER to Golgi Transport pathway
REACT_219139
Metabolism pathway
REACT_220924
COPII (Coat Protein 2) Mediated Vesicle Transport pathway
REACT_214469
Adaptive Immune System pathway
REACT_208174
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_213260
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75795
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_12507
COPII (Coat Protein 2) Mediated Vesicle Transport pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_11203
ER to Golgi Transport pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_111217
Metabolism pathway
REACT_11123
Membrane Trafficking pathway
REACT_205304
COPII (Coat Protein 2) Mediated Vesicle Transport pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_206143
Transport to the Golgi and subsequent modification pathway
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_209837
Membrane Trafficking pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_203486
ER to Golgi Transport pathway
REACT_237472
Asparagine N-linked glycosylation pathway
REACT_229531
Adaptive Immune System pathway
REACT_246972
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt A6QNT8
TrEMBL
UniProt Splice Variant
Entrez Gene 505089
UniGene Bt.104039 Bt.104321 Bt.105187 Bt.28249 Bt.68614
RefSeq NM_001101849
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC148994
GenPept AAI48995
RNA Seq Atlas 505089

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca