InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SEC24A

Summary

InnateDB Protein

IDBP-698564.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC24A

Protein Name

Protein transport protein Sec24A

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000040703

InnateDB Gene

IDBG-645809 (SEC24A)

Protein Structure

UniProt Annotation

Function

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0045714	regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0050714	positive regulation of protein secretion
GO:2000189	positive regulation of cholesterol homeostasis

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0030127	COPII vesicle coat
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR006895 Zinc finger, Sec23/Sec24-type
IPR006896 Sec23/Sec24, trunk domain
IPR006900 Sec23/Sec24, helical domain
IPR007123 Gelsolin-like domain
IPR012990 Sec23/Sec24 beta-sandwich

PFAM

PF00092
PF04810
PF04811
PF04815
PF00626
PF08033

PRINTS

PIRSF

SMART

SM00327

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6QNT8