Version 5.4
Bos taurus Gene: KLHL3
Summary
InnateDB Gene IDBG-645861.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHL3
Gene Name Kelch-like protein 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002796
Encoded Proteins
IDBP-698622
kelch-like 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146021:
This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:50666010-50774919
Strand Reverse strand
Band
Transcripts
ENSBTAT00000003625 ENSBTAP00000003625
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0050801 ion homeostasis
GO:0070294 renal sodium ion absorption
GO:0070936 protein K48-linked ubiquitination
GO:0072156 distal tubule morphogenesis
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000146021
View Gene Order
ENSMUSG00000014164
View Gene Order
Cross-References
SwissProt
TrEMBL J9JH85
UniProt Splice Variant
Entrez Gene 533364
UniGene Bt.92056
RefSeq XM_002689207 XM_005199048 XM_005199049 XM_005199050 XM_005199051 XM_005209403 XM_005209404 XM_005209405 XM_005209406 XM_612749
HUGO HGNC:6354
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02020380 DAAA02020381 DAAA02020382
GenPept
RNA Seq Atlas 533364

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca