InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: KLHL3

Summary

InnateDB Protein

IDBP-698622.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLHL3

Protein Name

kelch-like 3 (Drosophila)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003625

InnateDB Gene

IDBG-645861 (KLHL3)

Protein Structure

UniProt Annotation

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0050801	ion homeostasis
GO:0070294	renal sodium ion absorption
GO:0070936	protein K48-linked ubiquitination
GO:0072156	distal tubule morphogenesis

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt