InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EGR1

Summary

InnateDB Gene

IDBG-645986.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EGR1

Gene Name

early growth response protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010069

Encoded Proteins

IDBP-698750

early growth response protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 15545275

[Homo sapiens] EGR1 is an immediate early gene that is up-regulated by a multitude of growth factors, cytokines and environmental stresses to regulate LPS-induced SOCS1 transcription.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120738:
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:51438727-51442500

Strand

Forward strand

Band

Transcripts

ENSBTAT00000013284

ENSBTAP00000013284

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 447 interaction(s) predicted by orthology.

Predicted by orthology
Total	447 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0035035	histone acetyltransferase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0009749	response to glucose
GO:0030217	T cell differentiation
GO:0030509	BMP signaling pathway
GO:0032868	response to insulin
GO:0033233	regulation of protein sumoylation
GO:0035914	skeletal muscle cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0070498	interleukin-1-mediated signaling pathway
GO:0071310	cellular response to organic substance
GO:0071320	cellular response to cAMP
GO:0071371	cellular response to gonadotropin stimulus
GO:0071480	cellular response to gamma radiation
GO:0090090	negative regulation of canonical Wnt signaling pathway