InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EGR1

Summary

InnateDB Protein

IDBP-698750.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EGR1

Protein Name

early growth response protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013284

InnateDB Gene

IDBG-645986 (EGR1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 447 interaction(s) predicted by orthology.

Predicted by orthology
Total	447 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0035035	histone acetyltransferase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0009749	response to glucose
GO:0030217	T cell differentiation
GO:0030509	BMP signaling pathway
GO:0032868	response to insulin
GO:0033233	regulation of protein sumoylation
GO:0035914	skeletal muscle cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0070498	interleukin-1-mediated signaling pathway
GO:0071310	cellular response to organic substance
GO:0071320	cellular response to cAMP
GO:0071371	cellular response to gonadotropin stimulus
GO:0071480	cellular response to gamma radiation
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR021839 Protein of unknown function DUF3432
IPR021849 Protein of unknown function DUF3446

PFAM

PF00096
PF11914
PF11928

PRINTS

PIRSF

SMART

SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite