Version 5.4
Bos taurus Gene: ARHGAP26
Summary
InnateDB Gene IDBG-646139.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP26
Gene Name rho GTPase-activating protein 26
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000027151
Encoded Proteins
IDBP-698913
Rho GTPase activating protein 26
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145819:
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:55822283-56166010
Strand Forward strand
Band
Transcripts
ENSBTAT00000060996 ENSBTAP00000053583
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000145819
View Gene Order
ENSMUSG00000036452
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
fak_pathway
Signaling events mediated by focal adhesion kinase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.25336
RefSeq NM_001205522
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca