Version 5.4
Bos taurus Gene: DLL4
Summary
InnateDB Gene IDBG-646274.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLL4
Gene Name delta-like protein 4 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010361
Encoded Proteins
IDBP-699062
delta-like protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128917:
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:36577285-36586360
Strand Forward strand
Band
Transcripts
ENSBTAT00000013680 ENSBTAP00000013680
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005112 Notch binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001569 patterning of blood vessels
GO:0001974 blood vessel remodeling
GO:0003208 cardiac ventricle morphogenesis
GO:0003209 cardiac atrium morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003344 pericardium morphogenesis
GO:0007154 cell communication
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organismal development
GO:0008285 negative regulation of cell proliferation
GO:0010596 negative regulation of endothelial cell migration
GO:0035912 dorsal aorta morphogenesis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0050767 regulation of neurogenesis
GO:0060579 ventral spinal cord interneuron fate commitment
GO:0061074 regulation of neural retina development
GO:0061314 Notch signaling involved in heart development
GO:0072554 blood vessel lumenization
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:2000179 positive regulation of neural precursor cell proliferation
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000128917
View Gene Order
ENSMUSG00000027314
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_118614
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_118636
Signaling by NOTCH4 pathway
REACT_118862
Signaling by NOTCH3 pathway
REACT_160205
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
REACT_160089
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
REACT_160106
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_118721
Signaling by NOTCH2 pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_196643
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
REACT_189085
Disease pathway
REACT_196589
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199384
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_199412
Signaling by NOTCH2 pathway
REACT_199413
Signaling by NOTCH3 pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_199411
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199404
Signaling by NOTCH4 pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_196638
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_188257
Signal Transduction pathway
REACT_231152
Signaling by NOTCH pathway
REACT_196591
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
KEGG
hsa04330
Notch signaling pathway pathway
mmu04330
Notch signaling pathway pathway
INOH
INOH website
Notch signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
Notch signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.12263
RefSeq NM_001075779
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca