InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DLL4

Summary

InnateDB Protein

IDBP-699062.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLL4

Protein Name

delta-like protein 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013680

InnateDB Gene

IDBG-646274 (DLL4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0001974	blood vessel remodeling
GO:0003208	cardiac ventricle morphogenesis
GO:0003209	cardiac atrium morphogenesis
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0003344	pericardium morphogenesis
GO:0007154	cell communication
GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0008285	negative regulation of cell proliferation
GO:0010596	negative regulation of endothelial cell migration
GO:0035912	dorsal aorta morphogenesis
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0050767	regulation of neurogenesis
GO:0060579	ventral spinal cord interneuron fate commitment
GO:0061074	regulation of neural retina development
GO:0061314	Notch signaling involved in heart development
GO:0072554	blood vessel lumenization
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
GO:2000179	positive regulation of neural precursor cell proliferation

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001774 Delta/Serrate/lag-2 (DSL) protein
IPR001881 EGF-like calcium-binding domain
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011651 Notch ligand, N-terminal
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF01414
PF07645
PF07657
PF07974

PRINTS

PIRSF

SMART

SM00181
SM00051
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite