InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GLRA1

Summary

InnateDB Gene

IDBG-646345.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLRA1

Gene Name

Glycine receptor subunit alpha-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014395

Encoded Proteins

IDBP-699140

Glycine receptor subunit alpha-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145888:
The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:65025011-65112636

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000019143

ENSBTAP00000019143

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0016594	glycine binding
GO:0016934	extracellular-glycine-gated chloride channel activity
GO:0022824	transmitter-gated ion channel activity
GO:0030977	taurine binding

Biological Process

GO:0001508	action potential
GO:0001964	startle response
GO:0002087	regulation of respiratory gaseous exchange by neurological system process
GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0006936	muscle contraction
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0007340	acrosome reaction
GO:0007601	visual perception
GO:0007628	adult walking behavior
GO:0034220	ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0043576	regulation of respiratory gaseous exchange
GO:0050884	neuromuscular process controlling posture
GO:0050905	neuromuscular process
GO:0051970	negative regulation of transmission of nerve impulse
GO:0060012	synaptic transmission, glycinergic
GO:0060013	righting reflex
GO:0060080	regulation of inhibitory postsynaptic membrane potential
GO:1902476	chloride transmembrane transport
GO:2000344	positive regulation of acrosome reaction

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0034707	chloride channel complex
GO:0043231	intracellular membrane-bounded organelle
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060077	inhibitory synapse