InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GLRA1

Summary

InnateDB Protein

IDBP-699140.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLRA1

Protein Name

Glycine receptor subunit alpha-1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019143

InnateDB Gene

IDBG-646345 (GLRA1)

Protein Structure

UniProt Annotation

Function

The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Note=Defects in GLRA1 are the cause of inherited congenital myoclonus of Poll Hereford calves. It is an autosomal recessive disease characterized by hyperesthesia and myoclonic jerks of the skeletal musculature that occur both spontaneously and in response to sensory stimuli. {ECO:0000269PubMed:11178872}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0016594	glycine binding
GO:0016934	extracellular-glycine-gated chloride channel activity
GO:0022824	transmitter-gated ion channel activity
GO:0030977	taurine binding

Biological Process

GO:0001508	action potential
GO:0001964	startle response
GO:0002087	regulation of respiratory gaseous exchange by neurological system process
GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0006936	muscle contraction
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0007340	acrosome reaction
GO:0007601	visual perception
GO:0007628	adult walking behavior
GO:0034220	ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0043576	regulation of respiratory gaseous exchange
GO:0050884	neuromuscular process controlling posture
GO:0050905	neuromuscular process
GO:0051970	negative regulation of transmission of nerve impulse
GO:0060012	synaptic transmission, glycinergic
GO:0060013	righting reflex
GO:0060080	regulation of inhibitory postsynaptic membrane potential
GO:1902476	chloride transmembrane transport
GO:2000344	positive regulation of acrosome reaction

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0034707	chloride channel complex
GO:0043231	intracellular membrane-bounded organelle
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060077	inhibitory synapse

Protein Structure and Domains

PDB ID

InterPro

IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008127 Glycine receptor alpha
IPR008128 Glycine receptor alpha1

PFAM

PF02932
PF02931

PRINTS

PR00253
PR00252
PR01673
PR01674

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P57695