InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CAPN3

Summary

InnateDB Gene

IDBG-646349.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPN3

Gene Name

calpain-3

Synonyms

SKM-CALP

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008868

Encoded Proteins

IDBP-699147

calpain-3

IDBP-699148

calpain-3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092529:
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:37828797-37885860

Strand

Forward strand

Band

Transcripts

ENSBTAT00000011677	ENSBTAP00000011677
ENSBTAT00000011680	ENSBTAP00000011680

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0008307	structural constituent of muscle
GO:0016787	hydrolase activity
GO:0031402	sodium ion binding
GO:0031432	titin binding
GO:0032947	protein complex scaffold
GO:0055103	ligase regulator activity

Biological Process

GO:0001896	autolysis
GO:0006461	protein complex assembly
GO:0006508	proteolysis
GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration
GO:0030239	myofibril assembly
GO:0033234	negative regulation of protein sumoylation
GO:0043066	negative regulation of apoptotic process
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045214	sarcomere organization
GO:0045661	regulation of myoblast differentiation
GO:0045862	positive regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050790	regulation of catalytic activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0061061	muscle structure development
GO:0070315	G1 to G0 transition involved in cell differentiation
GO:0071277	cellular response to calcium ion
GO:0071472	cellular response to salt stress
GO:0072657	protein localization to membrane
GO:0097264	self proteolysis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000092529

View Gene Order

ENSMUSG00000079110

View Gene Order

Cross-References

SwissProt

TrEMBL

A0FJZ7 A6QP82 Q9GLD1 Q9TTH7

UniProt Splice Variant

Entrez Gene

281663

UniGene

Bt.3961

RefSeq

NM_174260 XM_005211549 XM_005211550 XM_005211553

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF087571 AF298809 BC149197 DAAA02028572 DAAA02028573 EF015889

GenPept

AAF23263 AAG22810 AAI49198 ABK20178

RNA Seq Atlas

281663