Version 5.4
Bos taurus Gene: CNOT8
Summary
InnateDB Gene IDBG-646366.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNOT8
Gene Name CCR4-NOT transcription complex subunit 8
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012086
Encoded Proteins
IDBP-699161
CCR4-NOT transcription complex, subunit 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23386060
[Homo sapiens] CNOT8 negatively regulates interferon IFN/STAT1 signalling pathway and its depletion results in enhanced response to viral infection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155508:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:68039858-68057466
Strand Forward strand
Band
Transcripts
ENSBTAT00000016027 ENSBTAP00000016027
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003676 nucleic acid binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0030014 CCR4-NOT complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000155508
View Gene Order
ENSMUSG00000020515
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
REACT_244119
Deadenylation of mRNA pathway
REACT_233572
Gene Expression pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
hsa03018
RNA degradation pathway
mmu03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BJH0
UniProt Splice Variant
Entrez Gene 533443
UniGene
RefSeq NM_001192774 XM_005209654 XM_005209655
HUGO HGNC:9207
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02020720
GenPept
RNA Seq Atlas 533443

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca