InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cnot8

Summary

InnateDB Gene

IDBG-176044.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cnot8

Gene Name

CCR4-NOT transcription complex, subunit 8

Synonyms

1500015I04Rik; 1810022F04Rik; AA536816; AU015770; AU043059

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020515

Encoded Proteins

IDBP-176046

CCR4-NOT transcription complex, subunit 8

IDBP-263677

CCR4-NOT transcription complex, subunit 8

IDBP-538094

CCR4-NOT transcription complex, subunit 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23386060

[Homo sapiens] CNOT8 negatively regulates interferon IFN/STAT1 signalling pathway and its depletion results in enhanced response to viral infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155508:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:58104153-58118594

Strand

Forward strand

Band

B1.3

Transcripts

ENSMUST00000020822	ENSMUSP00000020822
ENSMUST00000108843	ENSMUSP00000104471
ENSMUST00000134896	ENSMUSP00000116116
ENSMUST00000133923

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006417	regulation of translation
GO:0008284	positive regulation of cell proliferation
GO:0031047	gene silencing by RNA
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030014	CCR4-NOT complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000155508

View Gene Order

ENSBTAG00000012086

Not yet available

Pathways

NETPATH

REACTOME

REACT_244119

Deadenylation of mRNA pathway

REACT_233572

Gene Expression pathway

REACT_235784

Deadenylation-dependent mRNA decay pathway

KEGG

mmu03018

RNA degradation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_20514

Deadenylation of mRNA pathway

REACT_20639

Deadenylation-dependent mRNA decay pathway

REACT_71

Gene Expression pathway

KEGG

hsa03018

RNA degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.28910 Mm.399658

RefSeq

NM_026949 XM_006534102 XM_006534103 XM_006534104 XM_006534105 XM_006534106

OMIM

CCDS

CCDS24722

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas