Version 5.4
Bos taurus Gene: TTBK2
Summary
InnateDB Gene IDBG-646368.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTBK2
Gene Name tau-tubulin kinase 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006470
Encoded Proteins
IDBP-699164
tau tubulin kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128881:
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:38159317-38248606
Strand Reverse strand
Band
Transcripts
ENSBTAT00000008483 ENSBTAP00000008483
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007224 smoothened signaling pathway
GO:0018105 peptidyl-serine phosphorylation
GO:0042384 cilium assembly
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005814 centriole
GO:0005829 cytosol
GO:0035869 ciliary transition zone
GO:0036064 ciliary basal body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000128881
View Gene Order
ENSMUSG00000090100
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.78415
RefSeq NM_001206071 XM_005211593 XM_005211594 XM_005211595 XM_005211596 XM_005211597 XM_005211598 XM_005211599 XM_005211600
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca