Version 5.4
Homo sapiens Gene: TTBK2
Summary
InnateDB Gene IDBG-8101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTBK2
Gene Name tau tubulin kinase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128881
Encoded Proteins
IDBP-8105
tau tubulin kinase 2
IDBP-746686
IDBP-746207
IDBP-745961
IDBP-745786
IDBP-747460
IDBP-806694
tau tubulin kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:42738734-42920809
Strand Reverse strand
Band q15.2
Transcripts
ENST00000267890 ENSP00000267890
ENST00000562880 ENSP00000457385
ENST00000567485
ENST00000564431 ENSP00000455574
ENST00000567274 ENSP00000457489
ENST00000566931 ENSP00000454605
ENST00000567840 ENSP00000455734
ENST00000622375 ENSP00000479984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007224 smoothened signaling pathway
GO:0008219 cell death
GO:0018105 peptidyl-serine phosphorylation
GO:0042384 cilium assembly
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005814 centriole
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0035869 ciliary transition zone
GO:0036064 ciliary basal body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000090100
View Gene Order
ENSBTAG00000006470
Not yet available
Cross-References
SwissProt
TrEMBL H3BTY5
UniProt Splice Variant
Entrez Gene 146057
UniGene Hs.646511 Hs.727864 Hs.733489
RefSeq NM_173500 XM_005254173 XM_006720402 XM_006720403
HUGO HGNC:19141
OMIM 611695
CCDS CCDS42029
HPRD 10288
IMGT
EMBL AC068727 AC090510 AC090514
GenPept
RNA Seq Atlas 146057

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca