Homo sapiens Gene: TTBK2
Summary
InnateDB Gene IDBG-8101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTBK2
Gene Name tau tubulin kinase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128881
Encoded Proteins
tau tubulin kinase 2
tau tubulin kinase 2
Protein Structure
Entrez Gene
Summary This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:42738734-42920809
Strand Reverse strand
Band q15.2
Transcripts
ENST00000267890 ENSP00000267890
ENST00000562880 ENSP00000457385
ENST00000567485
ENST00000564431 ENSP00000455574
ENST00000567274 ENSP00000457489
ENST00000566931 ENSP00000454605
ENST00000567840 ENSP00000455734
ENST00000622375 ENSP00000479984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007224 smoothened signaling pathway
GO:0008219 cell death
GO:0018105 peptidyl-serine phosphorylation
GO:0042384 cilium assembly
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005814 centriole
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0035869 ciliary transition zone
GO:0036064 ciliary basal body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q6IQ55
TrEMBL H3BMY7 H3BQ25 H3BTY5 Q8IWY7
UniProt Splice Variant
Entrez Gene 146057
UniGene Hs.646511 Hs.727864 Hs.733489
RefSeq NM_173500 XM_005254173 XM_006720402 XM_006720403
HUGO HGNC:19141
OMIM 611695
CCDS CCDS42029
HPRD 10288
IMGT
EMBL AB020654 AC068727 AC090510 AC090514 AF525400 AK131372 BC041876 BC071556
GenPept AAH41876 AAH71556 AAO14996 BAA74870 BAD18523
ImmGen TTBK2 (murine)
RNA Seq Atlas 146057