Homo sapiens Gene: TTBK2

Summary
InnateDB Gene IDBG-8101.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol TTBK2
Gene Name tau tubulin kinase 2
Synonyms SCA11; TTBK
Species Homo sapiens
Ensembl Gene ENSG00000128881
Encoded Proteins
IDBP-8105 tau tubulin kinase 2
IDBP-746686
IDBP-746207
IDBP-745961
IDBP-745786
IDBP-747460
Entrez Gene
Summary This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15: 43030932-43213007
Strand Reverse strand
Band q15.2
Transcripts
ENST00000267890  ENSP00000267890
ENST00000562880  ENSP00000457385
ENST00000567485 
ENST00000564431  ENSP00000455574
ENST00000567274  ENSP00000457489
ENST00000566931  ENSP00000454605
ENST00000567840  ENSP00000455734
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein‑Protein  10
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0008219 cell death
GO:0018105 peptidyl-serine phosphorylation
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000090100 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000006470 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q6IQ55 
TrEMBL H3BMY7 H3BQ25 H3BTY5
UniProt Splice Variant
Entrez Gene 146057 
UniGene Hs.646511 Hs.727864 Hs.733489
RefSeq NM_173500 
HUGO 19141 
OMIM 611695
CCDS CCDS42029 
HPRD 10288
IMGT
EMBL AB020654 AC068727 AC090510 AC090514 AK131372 BC041876 BC071556
GenPept AAH41876  AAH71556  BAA74870  BAD18523 
ImmGen TTBK2 (murine) 
RNA Seq Atlas 146057