InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: UBR1

Summary

InnateDB Gene

IDBG-646369.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBR1

Gene Name

E3 ubiquitin-protein ligase UBR1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021087

Encoded Proteins

IDBP-699188

ubiquitin protein ligase E3 component n-recognin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159459:
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:38301493-38447561

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000028086

ENSBTAP00000028086

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0070728	leucine binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0030163	protein catabolic process
GO:0032007	negative regulation of TOR signaling
GO:0071233	cellular response to leucine