Bos taurus Gene: XPC | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-646437.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | XPC | ||||||||||||||
Gene Name | DNA repair protein complementing XP-C cells | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000007362 | ||||||||||||||
Encoded Proteins |
xeroderma pigmentosum, complementation group C
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154767:
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 22:58702013-58724435 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
DNA Damage Recognition in GG-NER pathway
Dual incision reaction in GG-NER pathway
Formation of incision complex in GG-NER pathway
Global Genomic NER (GG-NER) pathway
Nucleotide Excision Repair pathway
DNA Repair pathway
Dual incision reaction in GG-NER pathway
Global Genomic NER (GG-NER) pathway
Formation of incision complex in GG-NER pathway
Nucleotide Excision Repair pathway
DNA Repair pathway
DNA Damage Recognition in GG-NER pathway
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KEGG |
Nucleotide excision repair pathway
Nucleotide excision repair pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | E1BDJ1 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 524274 | ||||||||||||||
UniGene | Bt.45276 | ||||||||||||||
RefSeq | NM_001205908 XM_005223141 | ||||||||||||||
HUGO | HGNC:12816 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | DAAA02054616 | ||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | 524274 | ||||||||||||||