Version 5.4
Bos taurus Gene: SAV1
Summary
InnateDB Gene IDBG-646456.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAV1
Gene Name protein salvador homolog 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001539
Encoded Proteins
IDBP-699263
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151748:
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:43571065-43599997
Strand Reverse strand
Band
Transcripts
ENSBTAT00000002017 ENSBTAP00000002017
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001942 hair follicle development
GO:0007165 signal transduction
GO:0030216 keratinocyte differentiation
GO:0035329 hippo signaling
GO:0043065 positive regulation of apoptotic process
GO:0046620 regulation of organ growth
GO:0050680 negative regulation of epithelial cell proliferation
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060412 ventricular septum morphogenesis
GO:0060487 lung epithelial cell differentiation
GO:0060575 intestinal epithelial cell differentiation
GO:2000036 regulation of stem cell maintenance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000151748
View Gene Order
ENSMUSG00000021067
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_111102
Signal Transduction pathway
REACT_196537
Signaling by Hippo pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N6E1 Q08DE4
UniProt Splice Variant
Entrez Gene 516557
UniGene Bt.61728
RefSeq NM_001191362
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123794 DAAA02028698
GenPept AAI23795
RNA Seq Atlas 516557

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca