InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sav1

Summary

InnateDB Gene

IDBG-145302.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sav1

Gene Name

salvador homolog 1 (Drosophila)

Synonyms

1700040G09Rik; Salv; Sav; WW45; Wwp3; Wwp4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021067

Encoded Proteins

IDBP-145304

salvador homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151748:
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:69965012-69987002

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021467

ENSMUSP00000021467

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001942	hair follicle development
GO:0007165	signal transduction
GO:0030216	keratinocyte differentiation
GO:0035329	hippo signaling
GO:0043065	positive regulation of apoptotic process
GO:0046620	regulation of organ growth
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060044	negative regulation of cardiac muscle cell proliferation
GO:0060412	ventricular septum morphogenesis
GO:0060487	lung epithelial cell differentiation
GO:0060575	intestinal epithelial cell differentiation
GO:2000036	regulation of stem cell maintenance

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000151748

View Gene Order

ENSBTAG00000001539

Not yet available

Pathways

NETPATH

REACTOME

REACT_196537

Signaling by Hippo pathway

REACT_188257

Signal Transduction pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118607

Signaling by Hippo pathway

REACT_111102

Signal Transduction pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q8VEB2

TrEMBL

UniProt Splice Variant

Entrez Gene

64010

UniGene

RefSeq

NM_022028

OMIM

CCDS

CCDS25956

HPRD

IMGT

MGI ID

MGI:1927144

MGI Symbol

Sav1

EMBL

AJ292968 AK006655 BC019377

GenPept

AAH19377 BAB24691 CAC13977

RNA Seq Atlas

64010