Version 5.4
Bos taurus Gene: PIF1
Summary
InnateDB Gene IDBG-646478.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIF1
Gene Name ATP-dependent DNA helicase PIF1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007638
Encoded Proteins
IDBP-699290
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140451:
PIF1 is a 5-prime-to-3-prime DNA helicase that negatively regulates telomerase (see TERT; MIM 187270), a reverse transcriptase that maintains telomere length (Zhang et al., 2006 [PubMed 16522649]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:45317789-45324398
Strand Forward strand
Band
Transcripts
ENSBTAT00000010047 ENSBTAP00000010047
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003678 DNA helicase activity
GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity
GO:0033682 ATP-dependent 5'-3' DNA/RNA helicase activity
GO:0042162 telomeric DNA binding
GO:0043141 ATP-dependent 5'-3' DNA helicase activity
Biological Process
GO:0000723 telomere maintenance
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0032204 regulation of telomere maintenance
GO:0032508 DNA duplex unwinding
GO:0051974 negative regulation of telomerase activity
Cellular Component
GO:0000784 nuclear chromosome, telomeric region
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000140451
View Gene Order
ENSMUSG00000041064
View Gene Order
Cross-References
SwissProt
TrEMBL F1MMJ1
UniProt Splice Variant
Entrez Gene 534330
UniGene Bt.42378
RefSeq NM_001206052 XM_005211698
HUGO HGNC:26220
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02028729
GenPept
RNA Seq Atlas 534330

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca