Version 5.4
Homo sapiens Gene: PIF1
Summary
InnateDB Gene IDBG-16729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIF1
Gene Name PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140451
Encoded Proteins
IDBP-16731
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
IDBP-16733
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
IDBP-590810
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary PIF1 is a 5-prime-to-3-prime DNA helicase that negatively regulates telomerase (see TERT; MIM 187270), a reverse transcriptase that maintains telomere length (Zhang et al., 2006 [PubMed 16522649]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:64815632-64825668
Strand Reverse strand
Band q22.31
Transcripts
ENST00000268043 ENSP00000268043
ENST00000333425 ENSP00000328174
ENST00000559239 ENSP00000452792
ENST00000559872
ENST00000559522
ENST00000558380
ENST00000558547
ENST00000560444
ENST00000560504
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0010521 telomerase inhibitor activity
GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity
GO:0033682 ATP-dependent 5'-3' DNA/RNA helicase activity
GO:0042162 telomeric DNA binding
GO:0043141 ATP-dependent 5'-3' DNA helicase activity
GO:0051880 G-quadruplex DNA binding
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0000723 telomere maintenance
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0032204 regulation of telomere maintenance
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0032508 DNA duplex unwinding
GO:0051974 negative regulation of telomerase activity
Cellular Component
GO:0000784 nuclear chromosome, telomeric region
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041064
View Gene Order
ENSBTAG00000007638
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.112160
RefSeq NM_001286496 NM_001286497 NM_001286499 NM_025049
HUGO
OMIM
CCDS CCDS10195 CCDS66797
HPRD 10715
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca