InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MGLL

Summary

InnateDB Gene

IDBG-646512.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGLL

Gene Name

monoglyceride lipase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018248

Encoded Proteins

IDBP-699326

monoglyceride lipase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074416:
This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:60443564-60493810

Strand

Forward strand

Band

Transcripts

ENSBTAT00000024289

ENSBTAP00000024289

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0042803	protein homodimerization activity
GO:0047372	acylglycerol lipase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0009966	regulation of signal transduction
GO:0019369	arachidonic acid metabolic process
GO:0046464	acylglycerol catabolic process
GO:0050727	regulation of inflammatory response
GO:0051930	regulation of sensory perception of pain
GO:0060292	long term synaptic depression
GO:2000124	regulation of endocannabinoid signaling pathway