Version 5.4
Mus musculus Gene: Mgll
Summary
InnateDB Gene IDBG-167205.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mgll
Gene Name monoglyceride lipase
Synonyms AA589436; Magl; Mgl
Species Mus musculus
Ensembl Gene ENSMUSG00000033174
Encoded Proteins
IDBP-167209
monoglyceride lipase
IDBP-253568
monoglyceride lipase
IDBP-253570
monoglyceride lipase
IDBP-253572
monoglyceride lipase
IDBP-620562
monoglyceride lipase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:88724412-88828360
Strand Forward strand
Band D1
Transcripts
ENSMUST00000089449 ENSMUSP00000086872
ENSMUST00000113585 ENSMUSP00000109215
ENSMUST00000113582 ENSMUSP00000109212
ENSMUST00000113581 ENSMUSP00000109211
ENSMUST00000151699
ENSMUST00000150180
ENSMUST00000163271 ENSMUSP00000127374
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004806 triglyceride lipase activity
GO:0008289 lipid binding
GO:0016787 hydrolase activity
GO:0042803 protein homodimerization activity
GO:0047372 acylglycerol lipase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process
GO:0009966 regulation of signal transduction
GO:0019369 arachidonic acid metabolic process
GO:0019433 triglyceride catabolic process
GO:0046464 acylglycerol catabolic process
GO:0050727 regulation of inflammatory response
GO:0051930 regulation of sensory perception of pain
GO:0060292 long term synaptic depression
GO:2000124 regulation of endocannabinoid signaling pathway
Cellular Component
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000074416
View Gene Order
ENSBTAG00000018248
Not yet available
Pathways
NETPATH
REACTOME
REACT_245618
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_223625
GPCR downstream signaling pathway
REACT_199036
Acyl chain remodeling of DAG and TAG pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_247231
Arachidonate production from DAG pathway
REACT_188937
Metabolism pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_219232
Effects of PIP2 hydrolysis pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu00561
Glycerolipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19308
Arachidonate production from DAG pathway
REACT_2202
Effects of PIP2 hydrolysis pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_121122
Acyl chain remodeling of DAG and TAG pathway
REACT_494
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_14797
Signaling by GPCR pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.272197
RefSeq NM_001166249 NM_001166251 NM_011844
OMIM
CCDS CCDS20338 CCDS51843 CCDS51844
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca