Bos taurus Gene: MNAT1
Summary
InnateDB Gene IDBG-646752.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MNAT1
Gene Name CDK-activating kinase assembly factor MAT1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000030801
Encoded Proteins
CDK-activating kinase assembly factor MAT1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000020426:
The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:73153517-73363530
Strand Forward strand
Band
Transcripts
ENSBTAT00000043532 ENSBTAP00000041096
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008094 DNA-dependent ATPase activity
GO:0008270 zinc ion binding
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007512 adult heart development
GO:0021591 ventricular system development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051592 response to calcium ion
Cellular Component
GO:0005634 nucleus
GO:0005675 holo TFIIH complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
REACTOME
Cyclin A:Cdk2-associated events at S phase entry pathway
Cyclin E associated events during G1/S transition pathway
Cyclin D associated events in G1 pathway
Cyclin A/B1 associated events during G2/M transition pathway
RNA Polymerase I Transcription Termination pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Promoter Escape pathway
RNA Polymerase I Transcription Initiation pathway
mRNA Capping pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Polymerase II Pre-transcription Events pathway
Formation of RNA Pol II elongation complex pathway
Formation of the Early Elongation Complex pathway
RNA Polymerase II Transcription Elongation pathway
RNA Polymerase II Promoter Escape pathway
RNA Polymerase II Transcription Initiation pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
HIV Transcription Initiation pathway
RNA Polymerase II HIV Promoter Escape pathway
Formation of the HIV-1 Early Elongation Complex pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Transcription of the HIV genome pathway
Late Phase of HIV Life Cycle pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
Dual incision reaction in TC-NER pathway
Transcription-coupled NER (TC-NER) pathway
Dual incision reaction in GG-NER pathway
Formation of incision complex in GG-NER pathway
G1 Phase pathway
RNA Polymerase I Transcription pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Global Genomic NER (GG-NER) pathway
G1/S Transition pathway
Cell Cycle pathway
HIV Transcription Elongation pathway
RNA Polymerase II Transcription pathway
HIV Life Cycle pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
HIV Infection pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Mitotic G2-G2/M phases pathway
Nucleotide Excision Repair pathway
Gene Expression pathway
Disease pathway
DNA Repair pathway
Negative epigenetic regulation of rRNA expression pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
Transcription-coupled NER (TC-NER) pathway
RNA Polymerase I Transcription pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Formation of the Early Elongation Complex pathway
G1 Phase pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
Dual incision reaction in GG-NER pathway
RNA Polymerase II Transcription Initiation pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
RNA Polymerase II Promoter Escape pathway
Global Genomic NER (GG-NER) pathway
Formation of incision complex in GG-NER pathway
RNA Polymerase I Transcription Termination pathway
Cell Cycle pathway
Nucleotide Excision Repair pathway
Formation of RNA Pol II elongation complex pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
Cyclin D associated events in G1 pathway
DNA Repair pathway
Mitotic G2-G2/M phases pathway
RNA Polymerase II Transcription Elongation pathway
Cyclin A/B1 associated events during G2/M transition pathway
G1/S Transition pathway
RNA Polymerase II Pre-transcription Events pathway
Mitotic G1-G1/S phases pathway
mRNA Capping pathway
Gene Expression pathway
RNA Polymerase I Promoter Escape pathway
Cyclin E associated events during G1/S transition pathway
Dual incision reaction in TC-NER pathway
RNA Polymerase I Promoter Clearance pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase II Transcription pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
S Phase pathway
RNA Polymerase I Transcription Initiation pathway
KEGG
Basal transcription factors pathway
Nucleotide excision repair pathway
Basal transcription factors pathway
Nucleotide excision repair pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID NCI
Retinoic acid receptors-mediated signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.64302
RefSeq NM_001105409
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas