Version 5.4
Bos taurus Gene: SPTB
Summary
InnateDB Gene IDBG-646775.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPTB
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004732
Encoded Proteins
IDBP-699609
spectrin, beta, erythrocytic
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070182:
This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:77201411-77273590
Strand Reverse strand
Band
Transcripts
ENSBTAT00000006213 ENSBTAP00000006213
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0030506 ankyrin binding
GO:0046982 protein heterodimerization activity
GO:0051015 actin filament binding
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0007009 plasma membrane organization
GO:0030097 hemopoiesis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0008091 spectrin
GO:0009986 cell surface
GO:0014731 spectrin-associated cytoskeleton
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000070182
View Gene Order
ENSMUSG00000021061
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MKE9
UniProt Splice Variant
Entrez Gene 527711
UniGene Bt.111679 Bt.27241
RefSeq XM_003582733 XM_003586589
HUGO HGNC:11274
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02029410
GenPept
RNA Seq Atlas 527711

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca