Version 5.4
Bos taurus Gene: MPP5
Summary
InnateDB Gene IDBG-646786.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPP5
Gene Name MAGUK p55 subfamily member 5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011767
Encoded Proteins
IDBP-699620
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072415:
This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:79536643-79579325
Strand Forward strand
Band
Transcripts
ENSBTAT00000015625 ENSBTAP00000015625
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0002011 morphogenesis of an epithelial sheet
GO:0007009 plasma membrane organization
GO:0032287 peripheral nervous system myelin maintenance
GO:0035750 protein localization to myelin sheath abaxonal region
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0035749 myelin sheath adaxonal region
GO:0043219 lateral loop
GO:0043220 Schmidt-Lanterman incisure
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000072415
View Gene Order
ENSMUSG00000021112
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
REACT_248094
Cell-cell junction organization pathway
REACT_241978
Cell junction organization pathway
REACT_236746
Tight junction interactions pathway
REACT_223082
Cell-Cell communication pathway
KEGG
hsa04530
Tight junction pathway
mmu04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.18143
RefSeq NM_001205951 XM_005211982 XM_005211983
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca