InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MPP5

Summary

InnateDB Gene

IDBG-9828.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPP5

Gene Name

membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000072415

Encoded Proteins

IDBP-9830

membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

IDBP-599564

membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

IDBP-600992

membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

IDBP-599650

membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

IDBP-594108

membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:67241109-67335819

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000261681	ENSP00000261681
ENST00000554911
ENST00000556345	ENSP00000450550
ENST00000555925	ENSP00000451488
ENST00000554208
ENST00000557783	ENSP00000450656
ENST00000557237	ENSP00000451571

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0002011	morphogenesis of an epithelial sheet
GO:0007009	plasma membrane organization
GO:0032287	peripheral nervous system myelin maintenance
GO:0032288	myelin assembly
GO:0034329	cell junction assembly
GO:0035750	protein localization to myelin sheath abaxonal region
GO:0045216	cell-cell junction organization
GO:0070830	tight junction assembly
GO:0090002	establishment of protein localization to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0012505	endomembrane system
GO:0035749	myelin sheath adaxonal region
GO:0043219	lateral loop
GO:0043220	Schmidt-Lanterman incisure
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021112

View Gene Order

ENSBTAG00000011767

Not yet available

Pathways

NETPATH

REACTOME

REACT_19373

Tight junction interactions pathway

REACT_111155

Cell-Cell communication pathway

REACT_20676

Cell junction organization pathway

REACT_19331

Cell-cell junction organization pathway

KEGG

hsa04530

Tight junction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.622045 Hs.652312 Hs.692223 Hs.707523 Hs.740524

RefSeq

NM_001256550 NM_022474 XM_005268003

HUGO

OMIM

CCDS

CCDS58325 CCDS9779

HPRD

09508

IMGT

EMBL

GenPept

RNA Seq Atlas