Version 5.4
Bos taurus Gene: RDH12
Summary
InnateDB Gene IDBG-646797.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RDH12
Gene Name retinol dehydrogenase 12 precursor
Synonyms DSSDR2
Species Bos taurus
Ensembl Gene ENSBTAG00000012838
Encoded Proteins
IDBP-699633
retinol dehydrogenase 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139988:
The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:80159084-80167935
Strand Forward strand
Band
Transcripts
ENSBTAT00000017058 ENSBTAP00000017058
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004745 retinol dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0050662 coenzyme binding
Biological Process
GO:0008152 metabolic process
GO:0042572 retinol metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000139988
View Gene Order
ENSMUSG00000021123
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160156
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_188277
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_188260
Visual phototransduction pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
KEGG
hsa00830
Retinol metabolism pathway
mmu00830
Retinol metabolism pathway
INOH
PID NCI
cone_pathway
Visual signal transduction: Cones
rhodopsin_pathway
Visual signal transduction: Rods
Cross-References
SwissProt
TrEMBL A5PJU5 F1MD39
UniProt Splice Variant
Entrez Gene 369021
UniGene Bt.23153
RefSeq NM_183363 XM_005211942
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142243 DAAA02029474
GenPept AAI42244
RNA Seq Atlas 369021

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca