Version 5.4
Bos taurus Gene: FOS
Summary
InnateDB Gene IDBG-646869.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOS
Gene Name Proto-oncogene c-Fos
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004322
Encoded Proteins
IDBP-699709
Proto-oncogene c-Fos
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170345:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:86883739-86887169
Strand Forward strand
Band
Transcripts
ENSBTAT00000005660 ENSBTAP00000005660
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 162 interaction(s) predicted by orthology.
Predicted by orthology
Total 162 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0070412 R-SMAD binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007399 nervous system development
GO:0031668 cellular response to extracellular stimulus
GO:0034614 cellular response to reactive oxygen species
GO:0035914 skeletal muscle cell differentiation
GO:0042493 response to drug
GO:0045672 positive regulation of osteoclast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060395 SMAD protein signal transduction
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000170345
View Gene Order
ENSMUSG00000021250
View Gene Order
Pathways
NETPATH
REACTOME
REACT_218237
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_210286
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_224703
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_222278
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_224546
MyD88-independent cascade pathway
REACT_217035
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_227345
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_210224
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_206069
Cellular responses to stress pathway
REACT_213138
Immune System pathway
REACT_227036
MAP kinase activation in TLR cascade pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_215025
Cellular Senescence pathway
REACT_223848
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_225657
Oxidative Stress Induced Senescence pathway
REACT_225653
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_218091
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_216676
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_219586
MyD88 dependent cascade initiated on endosome pathway
REACT_216456
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_216714
Innate Immune System pathway
REACT_202074
FCERI mediated MAPK activation pathway
REACT_221197
Activation of the AP-1 family of transcription factors pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
REACT_217527
MyD88 cascade initiated on plasma membrane pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_18
IL6 pathway
NetPath_56
Prolactin pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_21326
Activation of the AP-1 family of transcription factors pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_120956
Cellular responses to stress pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_204811
Activation of the AP-1 family of transcription factors pathway
REACT_210065
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_188957
Cellular responses to stress pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_262171
MAP kinase activation in TLR cascade pathway
REACT_230745
Immune System pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_188820
Cellular Senescence pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_241786
MyD88-independent cascade pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_188530
FCERI mediated MAPK activation pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa04010
MAPK signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05140
Leishmaniasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu05210
Colorectal cancer pathway
mmu04010
MAPK signaling pathway pathway
mmu04662
B cell receptor signaling pathway pathway
mmu05200
Pathways in cancer pathway
mmu05140
Leishmaniasis pathway
mmu04380
Osteoclast differentiation pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
CD4 T cell receptor signaling pathway
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
ar_nongenomic_pathway
Nongenotropic Androgen signaling
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
lysophospholipid_pathway
LPA receptor mediated events
il2_1pathway
IL2-mediated signaling events
ps1pathway
Presenilin action in Notch and Wnt signaling
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
s1p_s1p2_pathway
S1P2 pathway
il12_2pathway
IL12-mediated signaling events
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
erbb1_downstream_pathway
ErbB1 downstream signaling
atf2_pathway
ATF-2 transcription factor network
il12_stat4pathway
IL12 signaling mediated by STAT4
ap1_pathway
AP-1 transcription factor network
reg_gr_pathway
Glucocorticoid receptor regulatory network
fgf_pathway
FGF signaling pathway
endothelinpathway
Endothelins
bcr_5pathway
BCR signaling pathway
tcrraspathway
Ras signaling in the CD4+ TCR pathway
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
hif1_tfpathway
HIF-1-alpha transcription factor network
gmcsf_pathway
GMCSF-mediated signaling events
rhoa_pathway
RhoA signaling pathway
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
foxm1pathway
FOXM1 transcription factor network
hnf3apathway
FOXA1 transcription factor network
pdgfrapathway
PDGFR-alpha signaling pathway
pdgfrbpathway
PDGFR-beta signaling pathway
il6_7pathway
IL6-mediated signaling events
telomerasepathway
Regulation of Telomerase
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.52605
RefSeq NM_182786
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca