InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FOS

Summary

InnateDB Protein

IDBP-699709.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOS

Protein Name

Proto-oncogene c-Fos

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005660

InnateDB Gene

IDBG-646869 (FOS)

Protein Structure

UniProt Annotation

Function

Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00978}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 162 interaction(s) predicted by orthology.

Predicted by orthology
Total	162 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0070412	R-SMAD binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007399	nervous system development
GO:0031668	cellular response to extracellular stimulus
GO:0034614	cellular response to reactive oxygen species
GO:0035914	skeletal muscle cell differentiation
GO:0042493	response to drug
GO:0045672	positive regulation of osteoclast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060395	SMAD protein signal transduction
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000837 Fos transforming protein
IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain

PFAM

PF00170
PF07716

PRINTS

PR00042

PIRSF

SMART

SM00338

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O77628

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

280795

UniGene

Bt.52605

RefSeq

NP_877587

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF069515 AY322482 BC118280 BT029837

GenPept

AAC21577 AAI18281 AAP84343 ABM21549