InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SPTLC2

Summary

InnateDB Gene

IDBG-646900.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPTLC2

Gene Name

serine palmitoyltransferase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020480

Encoded Proteins

IDBP-699746

serine palmitoyltransferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100596:
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:89756991-89852261

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000027289

ENSBTAP00000027289

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004758	serine C-palmitoyltransferase activity
GO:0016740	transferase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006686	sphingomyelin biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0046511	sphinganine biosynthetic process
GO:0046512	sphingosine biosynthetic process
GO:0046513	ceramide biosynthetic process