Version 5.4
| Bos taurus Gene: B2M | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-646936.3 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | B2M | ||||||||||||||||||
| Gene Name | Beta-2-microglobulin | ||||||||||||||||||
| Synonyms | B2M | ||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||
| Ensembl Gene | ENSBTAG00000012330 | ||||||||||||||||||
| Encoded Proteins |
Beta-2-microglobulin
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166710:
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009] This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 10:104139090-104145312 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | |||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
DAP12 interactions pathway
Amyloids pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
Class I MHC mediated antigen processing & presentation pathway
Immune System pathway
Adaptive Immune System pathway
Innate Immune System pathway
DAP12 signaling pathway
Disease pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
Endosomal/Vacuolar pathway pathway
ER-Phagosome pathway pathway
DAP12 signaling pathway
DAP12 interactions pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Interferon gamma signaling pathway
Nef mediated downregulation of MHC class I complex cell surface expression pathway
Amyloids pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Interferon Signaling pathway
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Disease pathway
Innate Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
Amyloids pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
ER-Phagosome pathway pathway
Endosomal/Vacuolar pathway pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
DAP12 interactions pathway
DAP12 signaling pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
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| KEGG |
Antigen processing and presentation pathway
Antigen processing and presentation pathway
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| INOH | |||||||||||||||||||
| PID NCI |
TCR signaling in naïve CD8+ T cells
Downstream signaling in naïve CD8+ T cells
IL12-mediated signaling events
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| Cross-References | |||||||||||||||||||
| SwissProt | P01888 | ||||||||||||||||||
| TrEMBL | Q6VUQ8 Q862Q3 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 783680 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | XM_001251107 XM_002691119 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | |||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB098926 AY325772 AY911322 BC118352 X69084 | ||||||||||||||||||
| GenPept | AAI18353 AAP78964 AAW82090 BAC56416 CAA48828 | ||||||||||||||||||
| RNA Seq Atlas | 280729 783680 | ||||||||||||||||||