InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: B2M

Summary

InnateDB Gene

IDBG-9902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B2M

Gene Name

beta-2-microglobulin

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000166710

Encoded Proteins

IDBP-9904

beta-2-microglobulin

IDBP-600049

beta-2-microglobulin

IDBP-601739

beta-2-microglobulin

IDBP-589718

beta-2-microglobulin

IDBP-596485

beta-2-microglobulin

IDBP-603988

beta-2-microglobulin

IDBP-591779

beta-2-microglobulin

IDBP-600211

beta-2-microglobulin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009]
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:44711477-44718877

Strand

Forward strand

Band

q21.1

Transcripts

ENST00000349264	ENSP00000340858
ENST00000558401	ENSP00000452780
ENST00000559720	ENSP00000453023
ENST00000561424	ENSP00000453191
ENST00000559916	ENSP00000453350
ENST00000557901	ENSP00000452861
ENST00000559907
ENST00000560681
ENST00000559220
ENST00000561139	ENSP00000453186
ENST00000560556
ENST00000544417	ENSP00000437604
ENST00000623550

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 188 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	188 [view]
Protein-Protein	175 [view]
Protein-DNA	9 [view]
Protein-RNA	4 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001895	retina homeostasis
GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002237	response to molecule of bacterial origin
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0006955	immune response
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0033077	T cell differentiation in thymus
GO:0042026	protein refolding
GO:0042493	response to drug
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087	innate immune response
GO:0046686	response to cadmium ion
GO:0050690	regulation of defense response to virus by virus
GO:0050776	regulation of immune response
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0031901	early endosome membrane
GO:0031905	early endosome lumen
GO:0042612	MHC class I protein complex
GO:0070062	extracellular vesicular exosome